Recent Publications

Maria C. Virgilio, W. Miguel Disbennett, Thomas Chen, Jay Lubow, Joshua D. Welch, Kathleen L. Collins, HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages

bioRxiv 2023.03.21.533528; doi:

Multi-omic single-cell velocity models epigenome-transcriptome interactions and improves cell fate prediction. Li C, Virgilio MC, Collins KL, Welch JD. Nat Biotechnol. 2023 Mar;41(3):387-398. 

doi: 10.1038/s41587-022-01476-y. Epub 2022 Oct 13. PMID: 36229609

Painter, M. M., Zimmerman, G. E., Merlino, M. S., Robertson, A. W., Terry, V. H., Ren, X., McLeod, M. R., Gomez-Rodriguez, L., Garcia, K. A., Leonard, J. A., Leopold, K. E., Neevel, A. J., Lubow, J., Olson, E., Piechocka-Trocha, A., Collins, D. R., Tripathi, A., Raghavan, M., Walker, B. D., Hurley, J. H., Sherman, D. H. & Collins, K. L. Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. 48109, 202008615 (2020).

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophages. Lubow J, Virgilio MC, Merlino M, Collins DR, Mashiba M, Peterson BG, Lukic Z, Painter MM, Gomez-Rivera F, Terry V, Zimmerman G, Collins KL. Elife. 2020 Mar 2;9. pii: e51035. doi: 10.7554/eLife.51035.PMID: 32119644

Zaikos TD, Terry VH, Sebastian Kettinger NT, Lubow J, Painter MM, Virgilio MC, Neevel A, Taschuk F, Onafuwa-Nuga A, McNamara LA, Riddell J 4th, Bixby D, Markowitz N, Collins KL. Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients. Cell Rep. 2018 Dec 26;25(13):3759-3773.e9. doi: 10.1016/j.celrep.2018.11.104. PubMed PMID: 30590047.

Zaikos TD, Painter MM, Sebastian Kettinger NT, Terry VH, Collins KL. Class 1-Selective Histone Deacetylase (HDAC) Inhibitors Enhance HIV Latency Reversal while Preserving the Activity of HDAC Isoforms Necessary for Maximal HIV Gene Expression. J Virol. 2018 Mar 15;92(6). doi: 10.1128/JVI.02110-17. Print 2018 Mar 15. PubMed PMID: 29298886; PubMed Central PMCID: PMC5827401.

Painter MM, Zaikos TD, Collins KL. Quiescence Promotes Latent HIV Infection and Resistance to Reactivation from Latency with Histone Deacetylase Inhibitors. J Virol. 2017 Dec 15;91(24). doi: 10.1128/JVI.01080-17. Print 2017 Dec 15. PubMed PMID: 29021396; PubMed Central PMCID: PMC5709582.

Sebastian NT, Zaikos TD, Terry V, Taschuk F, McNamara LA, Onafuwa-Nuga A, Yucha R, Signer RAJ, Riddell J IV, Bixby D, Markowitz N, Morrison SJ, Collins KL. CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo. PLoS Pathog. 2017 Jul;13(7):e1006509. doi: 10.1371/journal.ppat.1006509. eCollection 2017 Jul. PubMed PMID: 28732051; PubMed Central PMCID: PMC5540617.


Collins DR, Lubow J, Lukic Z, Mashiba M, Collins KL. Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes. PLoS Pathog. 2015 Jul;11(7):e1005054. doi: 10.1371/journal.ppat.1005054. eCollection 2015 Jul. PubMed PMID: 26186441; PubMed Central PMCID: PMC4506080.

Carter CC, Onafuwa-Nuga A, McNamara LA, Riddell J 4th, Bixby D, Savona MR, Collins KL. HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs. Nat Med. 2010 Apr;16(4):446-51. doi: 10.1038/nm.2109. Epub 2010 Mar 7. PubMed PMID: 20208541; PubMed Central PMCID: PMC2892382.

Collins KL, Chen BK, Kalams SA, Walker BD, Baltimore D. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature. 1998 Jan 22;391(6665):397-401. doi: 10.1038/34929. PubMed PMID: 9450757.

Review Articles

Virgilio MC, Collins KL. The Impact of Cellular Proliferation on the HIV-1 Reservoir. Viruses. 2020 Jan 21;12(2). pii: E127. doi: 10.3390/v12020127. Review.PubMed PMID: 31973022.

Sebastian NT, Collins KL. Targeting HIV latency: resting memory T cells, hematopoietic progenitor cells and future directions.Expert Rev Anti Infect Ther. 2014 Oct;12(10):1187-201. doi: 10.1586/14787210.2014.956094. Epub 2014 Sep 4. Review. PubMed PMID: 25189526; PubMed Central PMCID: PMC4291319.

Zaikos TD, Collins KL. Long-lived reservoirs of HIV-1. Trends Microbiol. 2014 Apr;22(4):173-5. doi: 10.1016/j.tim.2014.02.015. Epub 2014 Mar 15. PubMed PMID: 24641995; PubMed Central PMCID: PMC4048589.

Collins DR, Collins KL. HIV-1 accessory proteins adapt cellular adaptors to facilitate immune evasion. PLoS Pathog. 2014 Jan;10(1):e1003851. doi: 10.1371/journal.ppat.1003851. Epub 2014 Jan 23. Review. PubMed PMID: 24465204; PubMed Central PMCID: PMC3900642.